Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.62 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.62 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957740 | 0.89 | PRMT5 (0.65) | PRMT5WDR77CARM1 | |
| SCHEMBL19957734 | 0.85 | PRMT5 (0.67) | PRMT5WDR77CARM1 | |
| SCHEMBL19957562 | 0.83 | PRMT5 (0.67) | PRMT5WDR77CARM1 | |
| SCHEMBL19957936 | 0.82 | PRMT5 (0.65) | PRMT5WDR77 | |
| SCHEMBL19957638 | 0.81 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL19957589 | 0.81 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL19957752 | 0.81 | PRMT5 (0.67) | PRMT5WDR77CARM1 | |
| SCHEMBL19957735 | 0.80 | PRMT5 (0.65) | PRMT5WDR77CARM1 | |
| SCHEMBL19957828 | 0.80 | PRMT5 (0.66) | PRMT5WDR77 | |
| SCHEMBL19957519 | 0.80 | PRMT5 (0.64) | PRMT5WDR77CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |