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Sugi Predict / Compounds / SCHEMBL19957751

SCHEMBL19957751

SCHEMBL19957751

CN(C)CCOc1ccccc1OCC(=O)NCC(O)CN1CCc2ccccc2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 20/20 1.00
▸ WDR77 Q9BQA1 13/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16417568 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL16417637 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15935349 0.88 PRMT5 (1.00) PRMT5WDR77
SCHEMBL19957773 0.87 PRMT5 (0.77) PRMT5WDR77
SCHEMBL15935355 0.87 PRMT5 (0.80) PRMT5WDR77
SCHEMBL15825606 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15935478 0.85 PRMT5 (0.74) PRMT5WDR77
SCHEMBL15935404 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15935424 0.84 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15935394 0.84 PRMT5 (0.88) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2935243-B1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF EPIZYME INC (US) 2018-03-14 — — EP disclosed