Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.86 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.86 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.86 |
| ▸ | JAK2 | O60674 | 1/20 | 0.86 |
| ▸ | LCK | P06239 | 1/20 | 0.86 |
| ▸ | LYN | P07948 | 1/20 | 0.86 |
| ▸ | JAK1 | P23458 | 1/20 | 0.86 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.86 |
| ▸ | JAK3 | P52333 | 1/20 | 0.86 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.86 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1312033 | 0.92 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| Hydrochloric Acid SCHEMBL30189541 | 0.91 | SYK (0.98) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14981713 | 0.91 | SYK (0.83) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1354262 | 0.83 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14975783 | 0.83 | SYK (0.82) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14975885 | 0.82 | SYK (0.82) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1312569 | 0.82 | SYK (0.79) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL1355098 | 0.81 | SYK (1.00) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL2627143 | 0.81 | SYK (0.86) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14975680 | 0.80 | SYK (0.78) | SYKMAPK3MAPK1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071303-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071303-A1 | SYK INHIBITORS | SYK, LCK, MERTK | SYK 1/4885MAPK3 326/4885MAPK1 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.