Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.93 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | LPL | P06858 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67926 | 0.96 | MAPK1 (1.00) | MAPK1P2RX7LPLLIPG | |
| SCHEMBL1995890 | 0.92 | MAPK1 (0.84) | MAPK1P2RX7 | |
| SCHEMBL23755678 | 0.86 | MAPK1 (0.80) | MAPK1P2RX7LPLLIPG | |
| SCHEMBL16679197 | 0.85 | MAPK1 (0.79) | MAPK1P2RX7 | |
| SCHEMBL20867989 | 0.84 | MAPK1 (0.71) | MAPK1P2RX7LPLLIPG | |
| SCHEMBL20697262 | 0.82 | MAPK1 (0.73) | MAPK1P2RX7 | |
| SCHEMBL22548973 | 0.82 | MAPK1 (0.73) | MAPK1P2RX7 | |
| SCHEMBL28771140 | 0.82 | MAPK1 (0.72) | MAPK1P2RX7 | |
| SCHEMBL1586037 | 0.77 | MAPK1 (0.67) | MAPK1P2RX7LPLLIPG | |
| SCHEMBL18430042 | 0.76 | MAPK1 (0.65) | MAPK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |