Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30188942 | 1.00 | PARP1 (0.46) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL19637846 | 0.93 | PARP1 (0.47) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL19616821 | 0.93 | PARP1 (0.47) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL19948615 | 0.89 | PARP1 (0.46) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL19948468 | 0.88 | MTOR (0.37) | PARP1NR1H2NR1H3HDAC1MTOR | |
| SCHEMBL19948470 | 0.88 | MTOR (0.37) | PARP1NR1H2NR1H3HDAC1MTOR | |
| SCHEMBL22440404 | 0.86 | KRAS (0.49) | — | |
| SCHEMBL19948586 | 0.86 | KRAS (0.49) | — | |
| SCHEMBL19948582 | 0.86 | KRAS (0.49) | — | |
| SCHEMBL19617189 | 0.86 | PARP1 (0.42) | PARP1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373999-A1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-11-23 | — | — | US | disclosed |
| US-20230373999-A1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-11-23 | — | — | US | disclosed |
| US-10689377-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2020-06-23 | — | — | US | disclosed |
| US-10633381-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190144444-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2019-05-16 | — | — | US | disclosed |
| US-20180072723-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2018-03-15 | — | — | US | disclosed |
| US-20180072723-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144444-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | PARP1 1128/4885TMEM97 3851/4885SIGMAR1 4812/4885 |
| US-10633381-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | PARP1 1128/4885TMEM97 3851/4885SIGMAR1 4812/4885 |
| US-10689377-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | PARP1 1128/4885TMEM97 3851/4885SIGMAR1 4812/4885 |
| US-20180072723-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | PARP1 1128/4885TMEM97 3851/4885SIGMAR1 4812/4885 |
| US-20230373999-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | PARP1 1128/4885TMEM97 3851/4885SIGMAR1 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.