Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | IDE | P14735 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 6/20 | 0.58 |
| ▸ | CA1 | P00915 | 6/20 | 0.58 |
| ▸ | CA2 | P00918 | 6/20 | 0.58 |
| ▸ | CA9 | Q16790 | 6/20 | 0.58 |
| ▸ | HLCS | P50747 | 4/20 | 0.57 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20280336 | 1.00 | TDP1 (0.65) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL14523052 | 0.95 | TDP1 (0.70) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL12742901 | 0.92 | TDP1 (0.64) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL19427231 | 0.89 | F2 (0.63) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL19543512 | 0.89 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL20369791 | 0.89 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL12352865 | 0.89 | TDP1 (0.71) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL23430067 | 0.88 | TDP1 (0.62) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL24067575 | 0.88 | TDP1 (0.76) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL13609688 | 0.88 | TDP1 (0.73) | TDP1MEN1ABL1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048928-A1 | CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |