Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | MELK | Q14680 | 3/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19962972 | 0.91 | CREBBP (0.37) | CREBBPACVRL1ACVR1MELKMAPKAPK2 | |
| SCHEMBL19521325 | 0.81 | MELK (0.40) | CREBBPMELKMAPKAPK2ADORA2AADORA2B | |
| SCHEMBL19962909 | 0.80 | MELK (0.46) | CREBBPMELKMAPKAPK2ADORA2AADORA2B | |
| SCHEMBL19951557 | 0.79 | MAPKAPK2 (0.55) | CREBBPMELKMAPKAPK2ADORA2AADORA2B | |
| SCHEMBL19962992 | 0.79 | MAPKAPK2 (0.40) | CREBBPMELKMAPKAPK2ADORA2AADORA2B | |
| SCHEMBL19962993 | 0.79 | MAPKAPK2 (0.40) | CREBBPMELKMAPKAPK2ADORA2AADORA2B | |
| SCHEMBL19542106 | 0.79 | CREBBP (0.39) | CREBBPACVRL1ACVR1MELKMAPKAPK2 | |
| SCHEMBL19962978 | 0.78 | MELK (0.38) | CREBBPACVRL1ACVR1MELKMAPKAPK2 | |
| SCHEMBL19951564 | 0.78 | MELK (0.49) | CREBBPMELKMAPKAPK2ADORA2AADORA2B | |
| SCHEMBL19963019 | 0.78 | MAPKAPK2 (0.41) | CREBBPMELKMAPKAPK2ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049080-A1 | DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES | FGH BIOTECH, INC. (US) | 2018-03-15 | — | — | WO | disclosed |