Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 14/20 | 0.49 |
| ▸ | EED | O75530 | 5/20 | 0.49 |
| ▸ | RBBP4 | Q09028 | 5/20 | 0.49 |
| ▸ | SUZ12 | Q15022 | 5/20 | 0.49 |
| ▸ | AEBP2 | Q6ZN18 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17625019 | 0.81 | EZH2 (0.53) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL30785587 | 0.81 | CACNA1H (0.49) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18455533 | 0.79 | HPGD (0.53) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21251330 | 0.77 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29473787 | 0.74 | EZH2 (0.45) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL28598403 | 0.74 | EZH2 (0.45) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16116661 | 0.74 | MAPK14 (0.55) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL1694437 | 0.73 | KDM4E (0.53) | EZH2EEDRBBP4SUZ12AEBP2 | |
| Hydrochloric Acid SCHEMBL15648703 | 0.72 | KDM4E (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| Hydrochloric Acid SCHEMBL15709836 | 0.72 | KDM4E (0.51) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018045971-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发有限公司 | 2018-03-15 | — | — | WO | disclosed |