Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19949930 | 0.97 | MAP4K1 (0.44) | MAP4K1NTRK1KITFLT3NSD2 | |
| SCHEMBL19949764 | 0.89 | MAP4K1 (0.46) | MAP4K1NTRK1KITFLT3ALDH1A1 | |
| SCHEMBL19949817 | 0.82 | MAP4K1 (0.42) | MAP4K1ALDH1A1LRRK2PIK3CDUSP2 | |
| SCHEMBL19949869 | 0.80 | MAP4K1 (0.45) | MAP4K1NTRK1KITFLT3FGFR3 | |
| SCHEMBL19949830 | 0.80 | MAP4K1 (0.63) | MAP4K1NTRK1KITFLT3FGFR3 | |
| SCHEMBL19960797 | 0.79 | MAP4K1 (0.46) | MAP4K1NTRK1KITFLT3FGFR3 | |
| SCHEMBL19949834 | 0.79 | MAP4K1 (0.41) | MAP4K1NTRK1KITFLT3LRRK2 | |
| SCHEMBL19949874 | 0.76 | NTRK1 (0.44) | MAP4K1NTRK1KITFLT3LRRK2 | |
| SCHEMBL20791776 | 0.76 | MAP4K1 (0.51) | MAP4K1NTRK1KITFLT3LRRK2 | |
| SCHEMBL19949839 | 0.76 | MAP4K1 (0.41) | MAP4K1NTRK1KITFLT3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049214-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |