SCHEMBL19964822

SCHEMBL19964822

Cc1c(C(=O)OC(C)C)cc2cc(-c3nccs3)cn2c1C(C)N1CCOCC1

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
EED O75530 20/20 0.46
RBBP4 Q09028 20/20 0.46
SUZ12 Q15022 20/20 0.46
EZH2 Q15910 20/20 0.46
AEBP2 Q6ZN18 20/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21156574 0.89 EED (0.48) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21156529 0.85 EED (0.49) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21156575 0.84 EED (0.47) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21157342 0.84 EED (0.62) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21113380 0.84 EED (0.49) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21113447 0.84 EED (0.48) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21156586 0.83 EED (0.63) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21113438 0.83 EED (0.62) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21157290 0.83 EED (0.61) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21157284 0.83 EED (0.50) EEDRBBP4SUZ12EZH2AEBP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109790160-B Pyrido five-membered aromatic ring compound, preparation method and application thereof 上海海和药物研究开发股份有限公司 2022-11-15 CN disclosed
EP-3524602-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2019-08-14 EP disclosed
WO-2018045971-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 上海海和药物研究开发有限公司 2018-03-15 WO disclosed