Sugi Predict

Sugi Predict / Compounds / SCHEMBL19964847

SCHEMBL19964847

SCHEMBL19964847

Cc1c(C(=O)OC(C)C)cc2c(-c3ccc(N(C)C)cc3)ccn2c1C(C)N1CCOCC1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ EED O75530 13/20 0.45
▸ RBBP4 Q09028 13/20 0.45
▸ SUZ12 Q15022 13/20 0.45
▸ EZH2 Q15910 13/20 0.45
▸ AEBP2 Q6ZN18 13/20 0.45
▸ PIK3CD O00329 1/20 0.35
▸ PIK3CA P42336 1/20 0.35
▸ PIK3CB P42338 1/20 0.35
▸ PIK3CG P48736 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ MEN1 O00255 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ BAZ2B Q9UIF8 1/20 0.33
▸ BAZ2A Q9UIF9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21156583 0.91 EZH2 (0.44) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21157377 0.89 EED (0.46) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21156590 0.89 EED (0.47) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL19964849 0.89 EED (0.46) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL19964861 0.89 EED (0.49) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21113297 0.88 EED (0.46) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21113378 0.87 EED (0.47) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL19964482 0.83 EED (0.62) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21113257 0.83 EZH2 (0.46) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21157366 0.83 EED (0.46) EEDRBBP4SUZ12EZH2AEBP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109790160-B Pyrido five-membered aromatic ring compound, preparation method and application thereof 上海海和药物研究开发股份有限公司 2022-11-15 — — CN disclosed
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) 2021-04-06 — — US disclosed
EP-3524602-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Haihe Pharmaceutical Co., Ltd. (CN) 2019-08-14 — — EP disclosed
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF HAIHE BIOPHARMA CO. LTD. (CN) 2019-07-11 — — US disclosed
WO-2018045971-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 上海海和药物研究开发有限公司 2018-03-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10968215-B2 Pyrido five-element aromatic ring compound, preparation method therefor and use thereof EZH2, IKZF2, SUZ12 EED 41/4885RBBP4 288/4885SUZ12 3/4885
US-20190211010-A1 PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF EZH2, IKZF2, SUZ12 EED 41/4885RBBP4 288/4885SUZ12 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.