Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 2/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.37 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28886533 | 0.91 | EZH2 (0.37) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21113188 | 0.84 | EZH2 (0.35) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21113160 | 0.75 | EZH2 (0.38) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21156606 | 0.74 | EZH2 (0.34) | EZH2 | |
| SCHEMBL29986791 | 0.74 | EZH2 (0.34) | EZH2 | |
| SCHEMBL19964713 | 0.74 | EZH2 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL29986588 | 0.74 | EZH2 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21113102 | 0.73 | EZH2 (0.31) | EZH2ALDH1A1KDM4E | |
| SCHEMBL21251323 | 0.71 | EZH2 (0.37) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21113108 | 0.70 | EZH2 (0.43) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018045971-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发有限公司 | 2018-03-15 | — | — | WO | disclosed |