SCHEMBL19966385

SCHEMBL19966385

Cc1nc2c(F)cc(-c3nc(Nc4ccc(N5CCNC(C)C5)cn4)ncc3F)cc2n1N(C)C

nearest known ligand 0.71

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 18/20 0.71
CCND3 P30281 18/20 0.71
CDK6 Q00534 18/20 0.71
CDK1 P06493 11/20 0.71
CCNA2 P20248 11/20 0.71
CSF1R P07333 1/20 0.60
CDK2 P24941 2/20 0.56
CDK5 Q00535 1/20 0.56
CCNE2 O96020 1/20 0.54
PIM1 P11309 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19966387 0.90 CDK6 (0.69) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL17488811 0.88 CDK4 (0.70) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL17488855 0.88 CDK4 (0.70) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL19966523 0.87 CDK4 (0.72) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL18822776 0.83 CDK4 (1.00) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL18822838 0.82 CDK6 (1.00) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL18822837 0.82 CDK6 (1.00) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL18822762 0.82 CDK6 (1.00) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL19966520 0.81 CDK4 (0.61) CDK4CCND3CDK6CDK1CCNA2
SCHEMBL22166782 0.81 CCND3 (0.85) CDK4CCND3CDK6CDK1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018045957-A1 CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 江苏豪森药业集团有限公司 2018-03-15 WO disclosed