Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14476417 | 0.81 | TDP1 (0.39) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL19966587 | 0.81 | MEN1 (0.33) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL19953448 | 0.80 | MEN1 (0.33) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL30890984 | 0.78 | FOLH1 (0.43) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL15979029 | 0.77 | KMT2A (0.39) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL15979024 | 0.77 | MEN1 (0.39) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL23842466 | 0.76 | MEN1 (0.38) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL27390294 | 0.76 | MEN1 (0.38) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL14358527 | 0.76 | MEN1 (0.34) | MEN1MAPK1KMT2ACTSLFOLH1 | |
| SCHEMBL15979034 | 0.75 | MEN1 (0.37) | MEN1MAPK1KMT2ACTSLFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510033-B1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS AG (CH) | 2021-11-24 | — | — | EP | disclosed |
| WO-2018047081-A1 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS | NOVARTIS AG (CH) | 2018-03-15 | — | — | WO | disclosed |