SCHEMBL19966535

SCHEMBL19966535

CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5cc(C(=O)C(C)C)n(C(C)C)c5c4)n3)nc2)CC1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK6 Q00534 18/20 0.68
CDK4 P11802 11/20 0.68
CCND3 P30281 9/20 0.68
CDK1 P06493 7/20 0.68
CCNA2 P20248 5/20 0.68
CDK2 P24941 4/20 0.68
CCND1 P24385 4/20 0.68
DYRK2 Q92630 3/20 0.68
CCNE2 O96020 2/20 0.68
CIT O14578 1/20 0.68
GAK O14976 1/20 0.68
DYRK3 O43781 1/20 0.68
CCNT1 O60563 1/20 0.68
STK16 O75716 1/20 0.68
CCNK O75909 1/20 0.68
STK10 O94804 1/20 0.68
PRKD3 O94806 1/20 0.68
ABCB11 O95342 1/20 0.68
MAP4K4 O95819 1/20 0.68
EGFR P00533 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19966543 0.88 CDK6 (0.74) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL20740517 0.87 CDK6 (0.66) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL19966563 0.82 CDK6 (0.68) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL24632786 0.82 CDK6 (0.74) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL19966492 0.82 CDK6 (0.79) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL24632967 0.81 CCND3 (0.80) CDK6CDK4CCND3CDK1CCNA2
Abemaciclib SCHEMBL29423472 0.81 CDK4 (1.00) CDK6CDK4CCND3CDK1CCNA2
Abemaciclib SCHEMBL29591527 0.81 CDK4 (1.00) CDK6CDK4CCND3CDK1CCNA2
Abemaciclib SCHEMBL29356350 0.81 CDK4 (1.00) CDK6CDK4CCND3CDK1CCNA2
Abemaciclib SCHEMBL2487229 0.81 CDK4 (1.00) CDK6CDK4CCND3CDK1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109952295-B CDK4/6 inhibitor and preparation method and application thereof 江苏豪森药业集团有限公司 2021-04-06 CN disclosed
WO-2018045957-A1 CDK4/6 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 江苏豪森药业集团有限公司 2018-03-15 WO disclosed