Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 11/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951289 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951253 | 0.91 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951356 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951194 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951281 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951301 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951326 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951340 | 0.82 | MEN1 (0.61) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951206 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19951200 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357477-B2 | Anticancer compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180071258-A1 | ANTICANCER COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071258-A1 | ANTICANCER COMPOUNDS | RB1, MCL1, TP53 | SMN1; SMN2 2882/4885ALDH1A1 757/4885MEN1 603/4885 |
| US-10357477-B2 | Anticancer compounds | RB1, MCL1, TP53 | SMN1; SMN2 2882/4885ALDH1A1 757/4885MEN1 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.