Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | DDX3X | O00571 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12511127 | 0.77 | DPP4 (0.34) | TSHR | |
| SCHEMBL15492729 | 0.71 | MAPT (0.43) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL21233435 | 0.71 | DPP4 (0.32) | — | |
| SCHEMBL1063939 | 0.71 | MAPT (0.52) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL12597236 | 0.70 | MAPT (0.42) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL12989301 | 0.68 | MAPT (0.41) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL11682358 | 0.68 | MAPT (0.41) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL11770857 | 0.68 | MAPT (0.41) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL27634745 | 0.68 | MAPT (0.41) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL22350258 | 0.66 | MAPT (0.43) | MAPTMEN1KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047139-A1 | COMPOUNDS AS MODULATORS OF TIGIT SIGNALLING PATHWAY | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-15 | — | — | WO | disclosed |