Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.46 |
| ▸ | LTA4H | P09960 | 5/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19969548 | 1.00 | ACE (0.46) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL21168326 | 0.91 | ACE (0.46) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL21168325 | 0.91 | ACE (0.46) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL21168319 | 0.90 | ACE (0.45) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL21168285 | 0.90 | ACE (0.45) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL21999680 | 0.89 | ACE (0.44) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL24595272 | 0.89 | MME (0.49) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL18078113 | 0.89 | MME (0.49) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL22677493 | 0.89 | MME (0.49) | ACELTA4HMMEMMEL1ACE2 | |
| SCHEMBL19872246 | 0.89 | MME (0.49) | ACELTA4HMMEMMEL1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047139-A1 | COMPOUNDS AS MODULATORS OF TIGIT SIGNALLING PATHWAY | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-03-15 | — | — | WO | disclosed |