Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | GLP1R | P43220 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922897 | 0.87 | GCGR (0.55) | GCGRSLC6A2 | |
| SCHEMBL19923020 | 0.86 | GCGR (0.54) | GCGR | |
| SCHEMBL19940308 | 0.85 | GCGR (0.45) | GCGR | |
| SCHEMBL19940307 | 0.82 | GCGR (0.43) | GCGR | |
| SCHEMBL19922880 | 0.81 | GCGR (0.73) | GCGR | |
| SCHEMBL19922909 | 0.81 | GCGR (0.61) | GCGR | |
| SCHEMBL19940306 | 0.80 | GCGR (0.63) | GCGR | |
| SCHEMBL19922922 | 0.79 | GCGR (0.73) | GCGR | |
| SCHEMBL19922851 | 0.79 | GCGR (0.72) | GCGR | |
| SCHEMBL19940309 | 0.78 | GCGR (0.52) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048761-A1 | INDOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-15 | — | — | WO | disclosed |