Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 5/20 | 0.40 |
| ▸ | ICMT | O60725 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296636 | 0.92 | HRH3 (0.47) | HRH3GCGRICMTSLC6A2CYP17A1 | |
| SCHEMBL19940302 | 0.89 | GCGR (0.45) | HRH3GCGRICMT | |
| SCHEMBL19940303 | 0.86 | GCGR (0.43) | HRH3GCGRICMT | |
| SCHEMBL19922870 | 0.78 | GCGR (0.58) | GCGRSLC6A2 | |
| SCHEMBL19922853 | 0.77 | GCGR (0.59) | GCGRSLC6A2 | |
| SCHEMBL19923021 | 0.76 | GCGR (0.55) | GCGR | |
| SCHEMBL9033452 | 0.76 | — | — | |
| SCHEMBL9033432 | 0.76 | — | — | |
| SCHEMBL19922764 | 0.73 | GCGR (0.77) | GCGR | |
| SCHEMBL19922818 | 0.72 | GCGR (0.63) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048761-A1 | INDOLE DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-15 | — | — | WO | disclosed |