Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GRK2 | P25098 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971336 | 0.95 | TSHR (0.46) | TSHRHPGDALDH1A1CYP3A4ATM | |
| SCHEMBL19971329 | 0.92 | TSHR (0.43) | TSHRHPGDALDH1A1CYP3A4HCAR2 | |
| SCHEMBL19971254 | 0.89 | TSHR (0.40) | TSHRHPGDALDH1A1CYP3A4MEN1 | |
| SCHEMBL19971243 | 0.85 | TSHR (0.33) | TSHRHPGDBBOX1 | |
| SCHEMBL19971325 | 0.84 | TSHR (0.42) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL19971270 | 0.83 | TSHR (0.47) | TSHRALDH1A1THRBBBOX1MEN1 | |
| SCHEMBL19971310 | 0.81 | TSHR (0.36) | TSHRHPGD | |
| SCHEMBL19971237 | 0.81 | TSHR (0.55) | TSHRHPGDALDH1A1CYP3A4ATM | |
| SCHEMBL19971265 | 0.79 | TSHR (0.38) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL19971314 | 0.79 | TSHR (0.43) | TSHRTHRBBBOX1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530286-B2 | Sulfobetaine-based protein aggregation inhibitor for use in preventing aggregation of a protein | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2022-12-20 | — | — | US | disclosed |
| US-10995160-B2 | Protein aggregation inhibitor | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-20200332044-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2020-10-22 | — | — | US | disclosed |
| US-20190161563-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2019-05-30 | — | — | US | disclosed |
| US-20180118859-A1 | PROTEIN AGGREGATION INHIBITOR | OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| EP-3296314-A1 | PROTEIN AGGREGATION INHIBITOR | Osaka Organic Chemical Industry Ltd. (JP) | 2018-03-21 | — | — | EP | disclosed |