Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.52 |
| ▸ | FGR | P09769 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TEC | P42680 | 1/20 | 0.52 |
| ▸ | BMX | P51813 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971520 | 0.81 | BTK (0.56) | BTKFGRSRCTECBMX | |
| SCHEMBL9984792 | 0.81 | BTK (0.77) | BTKFGRSRCTECBMX | |
| SCHEMBL9983854 | 0.73 | BTK (0.80) | BTKFGRSRCTECBMX | |
| SCHEMBL12026211 | 0.70 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL2491369 | 0.69 | BTK (1.00) | BTKFGRSRCTECBMX | |
| SCHEMBL2528678 | 0.69 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL9984772 | 0.68 | BTK (1.00) | BTKFGRSRCTECBMX | |
| SCHEMBL2494374 | 0.66 | BTK (0.88) | BTKFGRSRCTECBMX | |
| SCHEMBL9984991 | 0.66 | BTK (0.88) | BTKFGRSRCTECBMX | |
| SCHEMBL2492092 | 0.66 | BTK (0.81) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | claimed |