Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9985266 | 0.87 | BTK (0.51) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9984648 | 0.87 | BTK (0.49) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9984355 | 0.87 | BTK (0.54) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9984360 | 0.86 | BTK (0.52) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2494710 | 0.84 | BTK (0.51) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2492538 | 0.83 | BTK (0.51) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2491965 | 0.83 | BTK (0.57) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2494292 | 0.82 | BTK (0.52) | BTKRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2463913 | 0.80 | BTK (0.65) | BTK | |
| SCHEMBL9985006 | 0.80 | BTK (0.54) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |