SCHEMBL19971531 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	13/20	0.40

▸	FGR	P09769	1/20	0.39

▸	SRC	P12931	1/20	0.39

▸	TEC	P42680	1/20	0.39

▸	BMX	P51813	1/20	0.39

▸	TYK2	P29597	1/20	0.37

▸	F10	P00742	1/20	0.35

▸	EP300	Q09472	2/20	0.35

▸	BCL6	P41182	1/20	0.34

▸	HTR1A	P08908	1/20	0.34

▸	CDK4	P11802	1/20	0.33

▸	CCND1	P24385	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2495237	0.89	BTK (0.52)	BTKFGRSRCTECBMX
SCHEMBL2462583	0.77	BTK (0.63)	BTKFGRSRCTECBMX
SCHEMBL2495235	0.76	BTK (0.52)	BTKFGRSRCTECBMX
SCHEMBL2462097	0.76	BTK (0.52)	BTKFGRSRCTECBMX
SCHEMBL2493454	0.74	BTK (0.53)	BTKFGRSRCTECBMX
SCHEMBL2491746	0.71	BTK (0.53)	BTKFGRSRCTECBMX
SCHEMBL2491968	0.71	BTK (0.53)	BTKFGRSRCTECBMX
SCHEMBL2490839	0.71	BTK (0.53)	BTKFGRSRCTECBMX
SCHEMBL2461586	0.71	BTK (0.51)	BTKFGRSRCTECBMX
SCHEMBL9985372	0.71	BTK (0.55)	BTKFGRSRCTECBMX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2365970-B1	PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS	GILEAD CONNECTICUT INC (US)	2018-03-21	—	—	EP	disclosed