Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL4611635 | 1.00 | SLC7A5 (0.41) | SLC7A5SLC1A3SLC1A2SLC1A1REN | |
| Leucine SCHEMBL1997232 | 1.00 | SLC7A5 (0.41) | SLC7A5SLC1A3SLC1A2SLC1A1REN | |
| Leucine SCHEMBL4663987 | 0.98 | SLC7A5 (0.43) | SLC7A5SLC1A3SLC1A2SLC1A1REN | |
| Leucine SCHEMBL4612139 | 0.98 | SLC7A5 (0.43) | SLC7A5SLC1A3SLC1A2SLC1A1REN | |
| Leucine SCHEMBL27683632 | 0.98 | SLC7A5 (0.43) | SLC7A5SLC1A3SLC1A2SLC1A1REN | |
| Leucine SCHEMBL6376065 | 0.98 | SLC7A5 (0.43) | SLC7A5SLC1A3SLC1A2SLC1A1REN | |
| Leucine SCHEMBL27686470 | 0.95 | SLC7A5 (0.45) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL14966502 | 0.95 | SLC7A5 (0.45) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL14966504 | 0.95 | SLC7A5 (0.45) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL7110075 | 0.94 | SLC7A5 (0.46) | SLC7A5SLC1A3SLC1A2SLC1A1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2337577-A1 | USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH ANTICANCER AGENTS | The Administrators of the Tulane Educational Fund (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2010036936-A2 | USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH ANTICANCER AGENTS | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2010-04-01 | — | — | WO | disclosed |
| US-6962904-B1 | Elastin peptide analogs and uses thereof | CONNECTIVE TISSUE IMAGINEERING (US) | 2005-11-08 | — | — | US | disclosed |
| US-6809075-B1 | Elastin peptide analogs and uses of same incombination with skin enhancing agents | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-10-26 | — | — | US | disclosed |
| US-6794362-B1 | TOPICAL COSMETIC APPLIED AS EMULSION, LOTION, SPRAY, POWDER, OINTMENT, CREAM, INCREASES SKIN'S TURGOR | CONNECTIVE TISSUE IMAGINEERING LLC | 2004-09-21 | — | — | US | disclosed |
| US-6506731-B1 | Peptide or peptide-like compound(s) of the present invention appear to aid the elasticity and/or turgor of the skin | CONNECTIVE TISSUE IMAGINEERING LLC | 2003-01-14 | — | — | US | disclosed |