Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628927 | 0.85 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL445392 | 0.85 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL445394 | 0.85 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL14949338 | 0.83 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL23303726 | 0.81 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL6951565 | 0.79 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL7361304 | 0.78 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1BCHEFAAHBUB1 | |
| SCHEMBL2616414 | 0.78 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL2466359 | 0.78 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1BCHEBUB1L3MBTL1 | |
| SCHEMBL8293842 | 0.78 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1BCHEFAAHBUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512858-B1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-08 | — | — | EP | disclosed |
| CN-109715634-B | Fused bicyclic inhibitors of MENIN-MLL interaction | 詹森药业有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-10975100-B2 | Fused bicyclic inhibitors of menin-MLL interaction | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| US-20200172556-A1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | JANSSEN PHARMACEUTICA NV (BE) | 2020-06-04 | — | — | US | disclosed |
| US-10611778-B2 | Fused bicyclic inhibitors of menin-MLL interaction | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-07 | — | — | US | disclosed |
| EP-3512858-A1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | Janssen Pharmaceutica NV (BE) | 2019-07-24 | — | — | EP | disclosed |
| US-20190218230-A1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | Janssen Pharmaceultica nv (BE) | 2019-07-18 | — | — | US | disclosed |
| WO-2018050684-A1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | JANSSEN PHARMACEUTICA NV (BE) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190218230-A1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | MLLT1, BMI1, MEN1 | HSP90AA1 3918/4885HSP90AB1 3596/4885BCHE 4132/4885 |
| US-10611778-B2 | Fused bicyclic inhibitors of menin-MLL interaction | MLLT1, BMI1, MEN1 | HSP90AA1 3918/4885HSP90AB1 3596/4885BCHE 4132/4885 |
| US-20200172556-A1 | FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION | MLLT1, BMI1, MEN1 | HSP90AA1 3918/4885HSP90AB1 3596/4885BCHE 4132/4885 |
| US-10975100-B2 | Fused bicyclic inhibitors of menin-MLL interaction | MLLT1, BMI1, MEN1 | HSP90AA1 3918/4885HSP90AB1 3596/4885BCHE 4132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.