SCHEMBL19976594

SCHEMBL19976594

O=C(c1c[nH]c2c(-n3nccn3)ncc(F)c12)C(O)N1CC2C=NN(c3ccccc3)C2C1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 1/20 0.31
HCRTR2 O43614 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19976577 0.89 HCRTR1 (0.30) HCRTR1HCRTR2
SCHEMBL16618711 0.84 CYP3A4 (0.36) HCRTR1HCRTR2
SCHEMBL16618803 0.66 CYP3A4 (0.48) HCRTR1HCRTR2
SCHEMBL2629099 0.65 CYP3A4 (0.59)
SCHEMBL16629058 0.63 CYP3A4 (0.46)
SCHEMBL16618919 0.63 CYP3A4 (0.46)
SCHEMBL16619020 0.61 CYP3A4 (0.65)
SCHEMBL2629101 0.56 CYP3A4 (0.61)
SCHEMBL16142677 0.56 CYP3A4 (0.44) HCRTR1HCRTR2
SCHEMBL15221339 0.56 CYP3A4 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9920073-B2 Compositions useful for inhibiting HIV-1 infection and methods using same DREXEL UNIVERSITY (US) 2018-03-20 US disclosed