Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000502 | 0.76 | NR1H2 (0.58) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL1999743 | 0.74 | NR1H2 (0.56) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL2001656 | 0.73 | NR1H2 (0.53) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL2001237 | 0.71 | NR1H2 (0.51) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL2001239 | 0.71 | NR1H2 (0.51) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL2003178 | 0.71 | NR1H2 (0.53) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL3504127 | 0.70 | NR1H2 (0.55) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL2001521 | 0.70 | NR1H2 (0.52) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL1999789 | 0.70 | NR1H2 (0.49) | NR1H2NR1H3CA12CA2CA9 | |
| SCHEMBL3507168 | 0.70 | NR1H2 (0.49) | NR1H2NR1H3CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960380-B2 | Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |