Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21084751 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAGPR119ALDH1A1CYP3A4 | |
| SCHEMBL30265882 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAGPR119ALDH1A1CYP3A4 | |
| SCHEMBL21084750 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAGPR119ALDH1A1CYP3A4 | |
| SCHEMBL19972526 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAGPR119ALDH1A1TP53 | |
| SCHEMBL31001695 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAGPR119ALDH1A1TP53 | |
| SCHEMBL31001708 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAGPR119TP53MAPT | |
| SCHEMBL31001683 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAGPR119ALDH1A1CYP3A4 | |
| SCHEMBL19972718 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAGPR119ALDH1A1CYP3A4 | |
| SCHEMBL19972506 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAGPR119TP53MAPT | |
| SCHEMBL31001666 | 0.80 | POLB (0.49) | SMN1; SMN2LMNAGPR119ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053267-A1 | INHIBITORS OF THE MENIN-MLL INTERACTION | VITAE PHARMACEUTICALS, INC. (US) | 2018-03-22 | — | — | WO | disclosed |