Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.39 |
| ▸ | JAK3 | P52333 | 11/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14474287 | 0.79 | JAK2 (0.38) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145009 | 0.78 | JAK2 (0.39) | JAK2JAK3PTK2JAK1CYP1A2 | |
| SCHEMBL2144767 | 0.77 | SYK (0.42) | JAK2JAK3PTK2CYP1A2 | |
| SCHEMBL3304622 | 0.77 | JAK2 (0.35) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2145126 | 0.76 | JAK2 (0.39) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144820 | 0.75 | GRM4 (0.39) | JAK2JAK3PTK2 | |
| SCHEMBL2144566 | 0.75 | GRM4 (0.39) | JAK2JAK3PTK2 | |
| SCHEMBL3309539 | 0.75 | GRM4 (0.41) | JAK2JAK3PTK2 | |
| SCHEMBL2143995 | 0.75 | JAK2 (0.38) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144893 | 0.75 | KIT (0.41) | JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053189-A2 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |