Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.57 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 1/20 | 0.49 |
| ▸ | BMX | P51813 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488067 | 0.85 | BTK (0.78) | BTKFGRSRCTECBMX | |
| SCHEMBL19981656 | 0.82 | BTK (0.35) | BTKPARP1 | |
| SCHEMBL2495852 | 0.78 | BTK (0.79) | BTKFGRSRCTECBMX | |
| SCHEMBL2528882 | 0.78 | BTK (0.72) | BTKFGRSRCTECBMX | |
| SCHEMBL2489319 | 0.78 | BTK (0.72) | BTKFGRSRCTECBMX | |
| SCHEMBL2494796 | 0.75 | BTK (0.77) | BTKFGRSRCTECBMX | |
| SCHEMBL2490380 | 0.75 | BTK (0.71) | BTKFGRSRCTECBMX | |
| SCHEMBL2489648 | 0.75 | BTK (0.71) | BTKFGRSRCTECBMX | |
| SCHEMBL2465016 | 0.73 | BTK (0.73) | BTKFGRSRCTECBMX | |
| SCHEMBL2495250 | 0.73 | BTK (0.73) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |