Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TEC | P42680 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489592 | 0.86 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL2489542 | 0.76 | BTK (0.73) | BTKFGRSRCTECBMX | |
| SCHEMBL2492835 | 0.75 | BTK (0.67) | BTKFGRSRCTECBMX | |
| SCHEMBL9985006 | 0.74 | BTK (0.54) | BTKFGRSRCTECBMX | |
| SCHEMBL2492464 | 0.73 | BTK (0.70) | BTKFGRSRCTECBMX | |
| SCHEMBL2462204 | 0.70 | BTK (0.83) | BTKFGRSRCTECBMX | |
| SCHEMBL9984366 | 0.70 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2489386 | 0.70 | BTK (0.70) | BTKFGRSRCTECBMX | |
| SCHEMBL2490637 | 0.69 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL9984235 | 0.69 | BTK (0.66) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |