Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.59 |
| ▸ | FGR | P09769 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | TEC | P42680 | 1/20 | 0.59 |
| ▸ | BMX | P51813 | 1/20 | 0.59 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984618 | 0.78 | BTK (0.75) | BTKFGRSRCTECBMX | |
| SCHEMBL2462218 | 0.78 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2491887 | 0.77 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL9984587 | 0.77 | BTK (0.71) | BTKFGRSRCTECBMX | |
| SCHEMBL2493067 | 0.77 | BTK (0.71) | BTKFGRSRCTECBMX | |
| SCHEMBL12045262 | 0.76 | BTK (0.66) | BTKFGRSRCTECBMX | |
| SCHEMBL2463010 | 0.75 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL2490032 | 0.75 | BTK (0.81) | BTKFGRSRCTECBMX | |
| SCHEMBL9985377 | 0.75 | BTK (0.57) | BTKFGRSRCTECBMX | |
| SCHEMBL2491369 | 0.75 | BTK (1.00) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |