Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.66 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.50 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31067462 | 0.95 | ESR2 (0.74) | NR1H2ESR2DPP4DPP8DPP9 | |
| SCHEMBL13337056 | 0.89 | DPP9 (0.58) | NR1H2ESR2DPP4DPP8DPP9 | |
| SCHEMBL12252190 | 0.85 | NR1H2 (0.74) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL29372093 | 0.85 | ESR2 (0.90) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL545619 | 0.85 | ESR2 (0.90) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL29388008 | 0.84 | NR1H2 (0.72) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL29507781 | 0.84 | NR1H2 (1.00) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL29587073 | 0.84 | NR1H2 (0.72) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL308035 | 0.84 | NR1H2 (1.00) | NR1H2ESR2ABHD6MAPK1HDAC1 | |
| SCHEMBL10256441 | 0.84 | NR1H2 (0.72) | NR1H2ESR2ABHD6MAPK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3365334-B1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMA CO LTD (JP) | 2024-07-17 | — | — | EP | disclosed |
| CN-113307772-B | Human plasma kallikrein inhibitors | 拜奥克里斯特制药公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-114340634-A | Heterocyclic compounds as kinase inhibitors | 诺维逊生物股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2018053222-A1 | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | RESEARCH TRAINGLE INSTITUTE (US) | 2018-03-22 | — | — | WO | disclosed |