Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | FGR | P09769 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981649 | 0.95 | BTK (0.37) | BTKROCK2ROCK1FGRSRC | |
| SCHEMBL19981492 | 0.89 | BTK (0.38) | BTKROCK2ROCK1FGRSRC | |
| SCHEMBL2492848 | 0.76 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL19981652 | 0.70 | BTK (0.52) | BTKROCK2ROCK1FGRSRC | |
| SCHEMBL2492441 | 0.67 | BTK (0.73) | BTKFGRSRCTECBMX | |
| SCHEMBL2465016 | 0.67 | BTK (0.73) | BTKFGRSRCTECBMX | |
| SCHEMBL2495250 | 0.67 | BTK (0.73) | BTKFGRSRCTECBMX | |
| SCHEMBL2492853 | 0.65 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL13363455 | 0.63 | BTK (0.55) | BTKFGRSRCTECBMX | |
| SCHEMBL2489648 | 0.63 | BTK (0.71) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |