Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 4/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464012 | 0.90 | BTK (0.52) | BTKSYKIGF1RCDK7CDK13 | |
| SCHEMBL9984917 | 0.77 | BTK (0.43) | BTKSYKIGF1RCDK13NTRK1 | |
| SCHEMBL2494331 | 0.76 | BTK (0.48) | BTK | |
| SCHEMBL12045185 | 0.76 | CCNA2 (0.48) | BTK | |
| SCHEMBL9984813 | 0.75 | BTK (0.45) | BTK | |
| SCHEMBL2461976 | 0.74 | BTK (0.50) | BTK | |
| SCHEMBL2489481 | 0.74 | BTK (0.44) | BTKCDK7CCNHMNAT1 | |
| SCHEMBL2463710 | 0.74 | BTK (0.51) | BTK | |
| SCHEMBL2492576 | 0.74 | BTK (0.67) | BTKIGF1R | |
| SCHEMBL2490547 | 0.73 | BTK (0.57) | BTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |