Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492283 | 0.92 | BTK (0.42) | BTKCYP2C9MCHR1HDAC1HTR2C | |
| SCHEMBL9984415 | 0.83 | BTK (0.36) | BTKMCHR1HDAC1HTR2CWNT1 | |
| SCHEMBL2490843 | 0.82 | BTK (0.46) | BTKCYP2C9MCHR1HDAC1HTR2C | |
| SCHEMBL2493470 | 0.80 | BTK (0.47) | BTKCYP2C9MCHR1HDAC1HTR2C | |
| SCHEMBL2491721 | 0.79 | BTK (0.55) | BTKHDAC1 | |
| SCHEMBL2490502 | 0.78 | BTK (0.38) | BTKCYP2C9 | |
| SCHEMBL9984518 | 0.77 | BTK (0.43) | BTKCLK2MAPK14ALDH1A1POLB | |
| SCHEMBL9984473 | 0.76 | BTK (0.40) | BTK | |
| SCHEMBL9985937 | 0.76 | BTK (0.40) | BTK | |
| SCHEMBL2489760 | 0.76 | BTK (0.40) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |