Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | MPL | P40238 | 10/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459218 | 0.81 | KIT (0.48) | BTKMPL | |
| SCHEMBL2466471 | 0.79 | BTK (0.45) | BTKMPLGSK3AGSK3BDYRK1A | |
| SCHEMBL2461976 | 0.78 | BTK (0.50) | BTKMPLEGFRGSK3AGSK3B | |
| SCHEMBL9985149 | 0.78 | BTK (0.43) | BTKMPL | |
| SCHEMBL2464530 | 0.74 | MPL (0.43) | BTKMPL | |
| SCHEMBL2462052 | 0.74 | BTK (0.64) | BTKMPL | |
| SCHEMBL19981663 | 0.73 | BTK (0.41) | BTKMPLEGFR | |
| SCHEMBL12045170 | 0.73 | GSK3A (0.41) | BTKMPLGSK3AGSK3BDYRK1A | |
| SCHEMBL9984355 | 0.72 | BTK (0.54) | BTKMPL | |
| SCHEMBL9984360 | 0.72 | BTK (0.52) | BTKMPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |