Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459218 | 0.85 | KIT (0.48) | BTKMAPK14NR1H4MPLKIT | |
| SCHEMBL13363419 | 0.84 | BTK (0.36) | BTKGSK3BGSK3ADYRK1AMKNK1 | |
| SCHEMBL2466471 | 0.81 | BTK (0.45) | BTKGSK3BGSK3ADYRK1AMKNK1 | |
| SCHEMBL12045170 | 0.77 | GSK3A (0.41) | BTKGSK3BGSK3ADYRK1AMKNK1 | |
| SCHEMBL9985149 | 0.76 | BTK (0.43) | BTKMPLKITSRCFLT3 | |
| SCHEMBL2461976 | 0.76 | BTK (0.50) | BTKGSK3BGSK3ADYRK1AMKNK1 | |
| SCHEMBL13363418 | 0.76 | BTK (0.38) | BTKGSK3BGSK3ADYRK1AMKNK1 | |
| SCHEMBL2464518 | 0.76 | BTK (0.44) | BTKGSK3BMAPK14NR1H4KIT | |
| SCHEMBL2464530 | 0.74 | MPL (0.43) | BTKMPLKITSRCFLT3 | |
| SCHEMBL2462052 | 0.72 | BTK (0.64) | BTKMPLSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |