Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984746 | 0.79 | BTK (0.45) | BTKMAPK14SMOCXCR1CXCR2 | |
| SCHEMBL9984917 | 0.71 | BTK (0.43) | BTK | |
| SCHEMBL2464530 | 0.70 | MPL (0.43) | BTKHDAC1 | |
| SCHEMBL9985149 | 0.66 | BTK (0.43) | BTK | |
| SCHEMBL2492909 | 0.64 | BTK (0.49) | BTKMAPK14SMOHDAC1 | |
| SCHEMBL2461857 | 0.64 | BTK (0.43) | BTKJAK2KDRHDAC1 | |
| SCHEMBL2494331 | 0.64 | BTK (0.48) | BTK | |
| SCHEMBL9984813 | 0.63 | BTK (0.45) | BTK | |
| SCHEMBL9985063 | 0.63 | BTK (0.45) | BTKJAK2MAPK14TP53 | |
| SCHEMBL12045185 | 0.63 | CCNA2 (0.48) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |