SCHEMBL19981787 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	12/20	0.41

▸	MELK	Q14680	3/20	0.36

▸	PARP1	P09874	2/20	0.32

▸	FGR	P09769	1/20	0.32

▸	SRC	P12931	1/20	0.32

▸	TEC	P42680	1/20	0.32

▸	BMX	P51813	1/20	0.32

▸	CDK4	P11802	1/20	0.32

▸	CCND1	P24385	1/20	0.32

▸	CPT2	P23786	1/20	0.31

▸	CPT1A	P50416	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9984459	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL2462328	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL9984873	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL2468853	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL2462198	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL2462193	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL9985028	0.90	BTK (0.48)	BTKMELKFGRSRCTEC
SCHEMBL9983983	0.83	BTK (0.52)	BTKMELKFGRSRCTEC
SCHEMBL9984875	0.81	BTK (0.47)	BTKMELKFGRSRCTEC
SCHEMBL2466052	0.81	BTK (0.47)	BTKMELKFGRSRCTEC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2365970-B1	PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS	GILEAD CONNECTICUT INC (US)	2018-03-21	—	—	EP	disclosed