Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 12/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9985180 | 1.00 | LCK (0.46) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL9984628 | 0.85 | BTK (0.52) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL9984593 | 0.85 | BTK (0.45) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL2495865 | 0.85 | JAK3 (0.47) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL2490832 | 0.84 | BTK (0.47) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL2490830 | 0.84 | BTK (0.47) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL9984843 | 0.81 | BTK (0.47) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL2492416 | 0.80 | SYK (0.43) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL19981782 | 0.80 | SYK (0.43) | LCKJAK3EGFRBTKSYK | |
| SCHEMBL9985840 | 0.79 | BTK (0.45) | LCKJAK3EGFRBTKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |