Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 13/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.51 |
| ▸ | FAP | Q12884 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12709891 | 0.87 | DPP7 (0.59) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL18774976 | 0.81 | DPP4 (0.61) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL18774982 | 0.81 | DPP4 (0.61) | DPP4DPP7DPP8DPP9FAP | |
| Hydrochloric Acid SCHEMBL11171586 | 0.81 | DPP4 (0.57) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL7939898 | 0.80 | DPP4 (0.66) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL12938959 | 0.79 | DPP7 (0.49) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL24323544 | 0.78 | DPP4 (0.63) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL17814291 | 0.78 | DPP4 (0.65) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL12709872 | 0.77 | DPP7 (0.46) | DPP4DPP7DPP8DPP9FAP | |
| SCHEMBL30314724 | 0.77 | DPP4 (0.63) | DPP4DPP7DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512832-B1 | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | RES TRIANGLE INST (US) | 2021-05-19 | — | — | EP | disclosed |
| WO-2018053222-A1 | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | RESEARCH TRAINGLE INSTITUTE (US) | 2018-03-22 | — | — | WO | disclosed |