Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.44 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2491658 | 0.83 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2491884 | 0.75 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2462583 | 0.74 | BTK (0.63) | BTKFGRSRCTECBMX | |
| SCHEMBL2495237 | 0.74 | BTK (0.52) | BTKFGRSRCTECBMX | |
| SCHEMBL2493454 | 0.69 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL9984996 | 0.68 | BTK (0.61) | BTKFGRSRCTECBMX | |
| SCHEMBL19981920 | 0.67 | BTK (0.39) | BTKFGRSRCTECBMX | |
| SCHEMBL2490839 | 0.67 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL2491968 | 0.67 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL2491746 | 0.67 | BTK (0.53) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |