Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.58 |
| ▸ | FGR | P09769 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TEC | P42680 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490923 | 0.91 | BTK (0.60) | BTKFGRSRCTECBMX | |
| SCHEMBL2491925 | 0.89 | BTK (0.58) | BTKFGRSRCTECBMX | |
| SCHEMBL2489542 | 0.88 | BTK (0.73) | BTKFGRSRCTECBMX | |
| SCHEMBL2495112 | 0.80 | BTK (0.64) | BTKFGRSRCTECBMX | |
| SCHEMBL2491965 | 0.80 | BTK (0.57) | BTKFGRSRCTECBMX | |
| SCHEMBL12025215 | 0.79 | BTK (0.55) | BTKFGRSRCTECBMX | |
| SCHEMBL2492502 | 0.79 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL2489592 | 0.79 | BTK (0.69) | BTKFGRSRCTECBMX | |
| SCHEMBL2493844 | 0.78 | BTK (0.52) | BTKFGRSRCTECBMX | |
| SCHEMBL2489386 | 0.78 | BTK (0.70) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |