Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.45 |
| ▸ | FGR | P09769 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12025215 | 0.82 | BTK (0.55) | BTKFGRSRCTECBMX | |
| SCHEMBL12025120 | 0.78 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL12025121 | 0.78 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL19981666 | 0.78 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL9985299 | 0.78 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL1423849 | 0.69 | BTK (0.51) | BTK | |
| SCHEMBL12045182 | 0.69 | BTK (0.48) | BTKFGRSRCTECBMX | |
| SCHEMBL2492576 | 0.68 | BTK (0.67) | BTKFGRSRCTECBMX | |
| SCHEMBL2492502 | 0.68 | BTK (0.53) | BTKFGRSRCTECBMX | |
| SCHEMBL1422358 | 0.68 | BTK (0.40) | BTKFGRSRCTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |