Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.45 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.34 |
| ▸ | AURKA | O14965 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459877 | 0.72 | BTK (0.56) | BTKCCND3CDK6CCNKCDK9 | |
| SCHEMBL17580874 | 0.66 | BTK (0.72) | BTKKDRLCKMAPK14 | |
| SCHEMBL2464982 | 0.65 | BTK (0.49) | BTKKDRLCKMAPK14ABL1 | |
| SCHEMBL2490514 | 0.64 | BTK (0.55) | BTKFLT3HDAC3 | |
| SCHEMBL2467008 | 0.63 | BTK (0.54) | BTK | |
| SCHEMBL1322776 | 0.63 | BTK (0.81) | BTK | |
| SCHEMBL1322473 | 0.62 | BTK (1.00) | BTK | |
| SCHEMBL1322908 | 0.60 | BTK (0.86) | BTK | |
| SCHEMBL2488701 | 0.60 | BTK (0.70) | BTKHDAC3 | |
| SCHEMBL19981728 | 0.60 | BTK (0.43) | BTKCCND3CDK6CDK9CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |