Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984448 | 0.92 | BTK (0.42) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL9984813 | 0.83 | BTK (0.45) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL2494331 | 0.79 | BTK (0.48) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL12045185 | 0.78 | CCNA2 (0.48) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL2489481 | 0.77 | BTK (0.44) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL2464012 | 0.69 | BTK (0.52) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL2493704 | 0.67 | BTK (0.51) | MAPK14SMOBTK | |
| SCHEMBL2492220 | 0.67 | BTK (0.65) | BTK | |
| SCHEMBL9984917 | 0.66 | BTK (0.43) | CDK2CCNA2CCNA1BTK | |
| SCHEMBL2492576 | 0.66 | BTK (0.67) | CDK2CCNA2CCNA1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |