Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 9/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21008492 | 0.83 | LRRK2 (0.47) | LRRK2SYKBTKTYK2MAP3K14 | |
| SCHEMBL22290756 | 0.75 | LRRK2 (0.38) | LRRK2SYK | |
| SCHEMBL23541137 | 0.74 | LRRK2 (0.41) | LRRK2SYKBTKTYK2MAP3K14 | |
| SCHEMBL254839 | 0.73 | LRRK2 (0.39) | LRRK2SYKALDH1A1 | |
| SCHEMBL23562583 | 0.73 | LRRK2 (0.41) | LRRK2SYKBTKTYK2MAP3K14 | |
| SCHEMBL1392881 | 0.72 | LRRK2 (0.38) | LRRK2SYK | |
| SCHEMBL16335331 | 0.72 | LRRK2 (0.38) | LRRK2SYKALDH1A1 | |
| SCHEMBL24958761 | 0.71 | LRRK2 (0.36) | LRRK2 | |
| SCHEMBL14925521 | 0.70 | LRRK2 (0.37) | LRRK2SYK | |
| SCHEMBL1392754 | 0.70 | BTK (0.45) | LRRK2SYKBTKTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |