Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 5/20 | 0.33 |
| ▸ | F10 | P00742 | 4/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | HTR1F | P30939 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981742 | 1.00 | MELK (0.34) | MELKBTKF10KCNH2ABL1 | |
| SCHEMBL19981938 | 0.92 | MELK (0.33) | MELKBTK | |
| SCHEMBL19981947 | 0.86 | BTK (0.36) | MELKBTKKCNH2ABL1HTR1F | |
| SCHEMBL19981860 | 0.86 | BTK (0.36) | MELKBTKKCNH2ABL1HTR1F | |
| SCHEMBL19981922 | 0.86 | BTK (0.36) | MELKBTKKCNH2ABL1HTR1F | |
| SCHEMBL9984623 | 0.77 | BTK (0.48) | MELKBTK | |
| SCHEMBL9984930 | 0.77 | BTK (0.48) | MELKBTK | |
| SCHEMBL9985008 | 0.77 | BTK (0.48) | MELKBTK | |
| SCHEMBL2464118 | 0.77 | BTK (0.48) | MELKBTK | |
| SCHEMBL2468755 | 0.77 | BTK (0.48) | MELKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |